The NIH Blueprint Non-Human Primate (NHP) Atlas consists of a suite of gene expression data, neuroanatomical
data and informatics tools for exploring the cellular and molecular architecture of the developing
rhesus macaque brain. The atlas includes:
Microdissection: Fine structure transcriptional profiling across prenatal and postnatal development for fine nuclear subdivisions of the prefrontal cortex, primary visual cortex, hippocampus, amygdala and ventral striatum
Macrodissection: Gross structure transcriptional profiling across postnatal development for the same structures
Cellular resolution in situ hybridization image data of five major brain regions during postnatal
developmental periods for genes clinically important for a variety of human neurodevelopmental disorders,
including prefrontal cortex, primary visual cortex, hippocampus, amygdala and ventral striatum.
Serial analysis of selected genes across the entire adult brain, focusing on cellular marker genes, genes
with cortical area specificity and gene families important to neural function.
ISH Anatomic Search: Detailed gene expression search on the postnatal developmental ISH data based on expert annotation
Reference Data: Postnatal developmental stage-specific reference series, consisting of magnetic resonance imaging (MRI) and Nissl histology to provide a neuroanatomical context for the gene expression data.
These data and tools are designed to provide a valuable public resource for researchers and educators to explore neurodevelopment in non-human primates, and a key evolutionary link between other Web-based gene expression atlases for adult and developing mouse and human brain.
The NIH Blueprint Non-Human Primate (NHP) Atlas, http://www.blueprintnhpatlas.org,
is funded from Federal funds from the National Institutes of Mental Health, Department of Health and Human Services, under Contract HHSN-271-2008-0047-C to the Allen Institute for Brain Science (Seattle, WA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.